Dr. Singh joins our podcast today to reveal fascinating research behind a compound called Urolithin A. This natural mitophagy activator has the potential to increase healthspan and lifespan, improve athletic performance, and support a healthy heart rate variability. He explains why many of us can't get the benefits of this powerful compound by simply eat pomegranates each day and why supplementation is necessary to achieve optimal levels within the body. Also stay tuned to for his top tips for anti-aging and longevity!
Dr. Singh is currently Chief Medical Officer at Amazentis, a lifesciences company based in Switzerland that discovers and develops next generation natural compounds targeting improvements in mitochondrial health. In particular, Dr. Singh has designed and led the clinical development program over the last 7 years for the natural mitophagy activator, Urolithin A (also known as Mitopure) that has led to the commercial launch of several branded consumer health products targeting improvements in cellular health. Dr. Singh received his medical training (MD) in Internal Medicine from the Armed Forces Medical College in India and a PhD in Immunology from the University of Connecticut Health Center. He also holds an executive MBA from Ecole Polytechnique Federal de Lausanne in Switzerland. He has authored over 30 articles in top peer-reviewed journals, holds over 10 patents and has designed and led over 40 clinical trials over the last 15 yrs.
0:53 Welcome to the show!
3:35 Dr. Singh’s bio
4:56 Welcome Dr. Singh to the podcast
5:55 How he discovered Urolithin A
8:07 How to naturally produce Urolithin A
9:37 Ellagic acids & Polyphenols
10:45 Why don’t we produce this compound anymore?
11:40 How to increase production
13:27 How & why to test Urolithin A levels
15:52 Can we supplement without testing?
17:12 What is Mitophagy?
18:34 *Coast Ad*
20:010 Mitophagy vs Autophagy
20:58 Benefits of supporting Mitophagy
22:24 Studies on physical performance & mobility
24:22 Studies on overtraining
26:17 What biomarkers can we observe?
26:55 Capsules vs Powder
28:31 What should we expect to feel?
30:04 Tracking metrics like HRV
32:08 Top tips for longevity & health span
32:42 Best practices for supplementing
35:23 How to learn more about Mitopure
36:24 His final piece of advice
38:12 Thanks for tuning in!
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Clinical study article showing that only upto 40% of folks have the gut microbiome that can convert dietary precursors into UA and that Timeline product containing a calibrated dose of Mitopure can deliver >6-fold higher UA levels than a glass of 100% pomegranate juice https://www.nature.com/articles/s41430-021-00950-1
- A great review article around all the different health benefits of UA https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(21)00118-0
- A first human study showing improvement in mitochondrial health in muscle of healthy adults https://www.nature.com/articles/s42255-019-0073-4
The Timeline website blog is a great place to learn more https://www.timelinenutrition.com/blog and also some previous podcasts on the topic http://www.llamapodcast.com/anurag-singh/ and https://daveasprey.com/mitopure-anurag-singh-877/
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