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154: True Age: Cutting-Edge Research to Help Turn Back the Clock with Dr. Morgan Levine

Jul 18, 2022 | Season 3


We dive into the fascinating topics of longevity, healthspan and biological age this week with Dr. Morgan Levine. She explains the differences between healthspan & lifespan, as well as biological age & chronological age. She also shares the best testing options currently available to assess our biological age, along with what the research is showing makes the greatest impact such as fasting, caloric restriction, stress reduction and sleep.

Morgan Levine is an assistant professor of pathology at Yale University School of Medicine. Her research focuses on the science of biological aging, specifically using bioinformatics to quantify the aging process and test how lifestyle and pharmaceutical interventions alter the rate of aging. As a leading voice in the field of aging and longevity science, she has been featured in media outlets such as CNN, The Guardian, Time, Newsweek, The Huffington Post, the BBC, and many more. She also appeared in the DocuSeries by Netflix and Goop, alongside Gwyneth Paltrow, which was released in early 2020. She is the author of True Age: Cutting-Edge Research to Help Turn Back the Clock.


0:54 Welcome to the show!

5:01 Dr. Morgan Levine’s Bio

5:47 Welcome Dr. Levine

6:56 Her definition: Healthspan vs Lifespan

7:51 Her personal health goal

8:37 How long can we live?

9:19 Chronological & Biological age

10:59 Testing options for biological age

12:21 Renee’s biological age tests

16:08 DNA methylation & Epigenetics

18:44 Her thoughts on telomeres & telomerase

20:10 How can we motivate people?

22:20 The role of genetics vs behavior

23:13 The role of stress on aging

24:38 Difference in longevity between men & women

26:55 *Women’s Healing Vacation Ad*

28:49 Why do women have a longevity advantage?

30:43 Really interesting animal studies!

31:33 The Horvath Clock

33:06 Senescence cells & the aging process

35:13 Caloric restriction & fasting

38:31 Dr. Levine as a biohacker

39:55 Exercise for longevity

412:01 How do you know what’s working?

42:53 Can genetics guide our exercise?

44:11 *Othership breathwork app

47:18 The importance of sleep quality & quantity

49:12 ApoE gene & health risks

53:35 “Ageotypes”

58:12 Does social connection play a role?

1:00:06 Her personal health choices

1:01:17 The future of cellular reprogramming

1:04:21 What are the best biomarkers to track?

1:06:45 Her final piece of advice

1:07:12 Thanks for tuning in!



Book: True Age




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